---
id: "claim:a-human-commons-cell-atlas-reveals-cell-type-specificity-for-oas1-isoforms-2024-37ce81bf37:2ce12d82b846d7508c10"
kind: "claim"
title: "Isoform expression can vary substantially while total gene expression stays constant."
description: ""
url: "https://sina.bio/claim/isoform-expression-can-vary-substantially-while-total-gene-expression-s-8901e2ee"
---

# Isoform expression can vary substantially while total gene expression stays constant.

## Content

Isoform expression can vary substantially while total gene expression stays constant.

## Metadata

```json
{
  "claim_position": 58,
  "source_publication_id": "version:a-human-commons-cell-atlas-reveals-cell-type-specificity-for-oas1-isoforms--2024-03-24-biorxiv",
  "source_work_id": "work:a-human-commons-cell-atlas-reveals-cell-type-specificity-for-oas1-isoforms"
}
```

## Connections (2)

### A human commons cell atlas reveals cell type specificity for OAS1 isoforms

- ID: `version:a-human-commons-cell-atlas-reveals-cell-type-specificity-for-oas1-isoforms--2024-03-24-biorxiv`
- Kind: `publication`
- Direction: `incoming`
- URL: <https://sina.bio/publication/a-human-commons-cell-atlas-reveals-cell-type-specificity-for-oas1-isoforms>

This publication contains this grounded claim.

> The expression of isoforms within genes can vary greatly, even when the overall gene expression remains unchanged

Source: 2024-03-24-biorxiv.pdf — <https://sina.bio/source/2024-03-24-biorxiv-pdf>

### Isoform cell-type specificity in the mouse primary motor cortex

- ID: `version:isoform-cell-type-specificity-in-the-mouse-primary-motor-cortex--2021-10-06-nature`
- Kind: `publication`
- Direction: `outgoing`
- URL: <https://sina.bio/publication/isoform-cell-type-specificity-in-the-mouse-primary-motor-cortex>

This publication is cited in support of this claim.

> Isoform-level Human CCA
> The expression of isoforms within genes can vary greatly, even when the overall gene
> expression remains unchanged (Booeshaghi et al. 2021). This information is lost in currently
> published atlases, which fail to quantify transcript isoforms. We hypothesized that OAS1
> . CC-BY 4.0 International license available under a

Source: 2024-03-24-biorxiv.pdf — <https://sina.bio/source/2024-03-24-biorxiv-pdf>