---
id: "claim:decrease-in-ace2-mrna-expression-in-aged-mouse-lung-2020-04-05-biorxiv:69279f7830052e7d51fe"
kind: "claim"
title: "An age-associated shift in ciliated-cell abundance likely contributes to decreased lung ACE2 expression."
description: ""
url: "https://sina.bio/claim/an-age-associated-shift-in-ciliated-cell-abundance-likely-contributes-t-a4479efc"
---

# An age-associated shift in ciliated-cell abundance likely contributes to decreased lung ACE2 expression.

## Content

An age-associated shift in ciliated-cell abundance likely contributes to decreased lung ACE2 expression.

## Metadata

```json
{
  "claim_position": 30,
  "source_publication_id": "version:decrease-in-ace2-mrna-expression-in-aged-mouse-lung--2020-04-05-biorxiv",
  "source_work_id": "work:decrease-in-ace2-mrna-expression-in-aged-mouse-lung"
}
```

## Connections (2)

### Decrease in ACE2 mRNA expression in aged mouse lung

- ID: `version:decrease-in-ace2-mrna-expression-in-aged-mouse-lung--2020-04-05-biorxiv`
- Kind: `publication`
- Direction: `incoming`
- URL: <https://sina.bio/publication/decrease-in-ace2-mrna-expression-in-aged-mouse-lung>

This publication contains this grounded claim.

> The decrease in ​ACE2 mRNA expression with age in lungs is likely due to two underlying phenomena: a reduction of ​ACE2 mRNA in ciliated cells, and a shift in ciliated cell abundance with age (Figure 1c, Supp. Fig 4).

Source: 2020-04-05-biorxiv.pdf — <https://sina.bio/source/2020-04-05-biorxiv-pdf>

### Reduced ACE2 mRNA in ciliated cells and a significant age-associated shift in ciliated-cell abundance likely contributed

- ID: `result:decrease-in-ace2-mrna-expression-in-aged-mouse-lung-2020-04-05-biorxiv:a8cdefe78c04211c594b`
- Kind: `result`
- Direction: `incoming`
- URL: <https://sina.bio/result/reduced-ace2-mrna-in-ciliated-cells-and-a-significant-age-associated-sh-e40a558a>

This claim supports this result.