---
id: "claim:determining-gene-specificity-from-multivariate-single-cell-rna-sequencing-data-4e791ab86b:5ac7542ff8571c67ae46"
kind: "claim"
title: "Cell type the dominant source of variation in PBMCs, but also this variation can be largely localized to classical monoc"
description: "Cell type the dominant source of variation in PBMCs, but also this variation can be largely localized to classical monocytes (Fig. 4b)."
url: "https://sina.bio/claim/cell-type-the-dominant-source-of-variation-in-pbmcs-but-also-this-varia-9d40e2e6"
---

# Cell type the dominant source of variation in PBMCs, but also this variation can be largely localized to classical monoc

Cell type the dominant source of variation in PBMCs, but also this variation can be largely localized to classical monocytes (Fig. 4b).

## Content

Cell type the dominant source of variation in PBMCs, but also this variation can be largely localized to classical monocytes (Fig. 4b).

## Metadata

```json
{
  "claim_position": 200,
  "source_publication_id": "version:determining-gene-specificity-from-multivariate-single-cell-rna-sequencing-data--2025-11-24-biorxiv",
  "source_work_id": "work:determining-gene-specificity-from-multivariate-single-cell-rna-sequencing-data"
}
```

## Connections (2)

### Determining gene specificity from multivariate single-cell RNA sequencing data

- ID: `version:determining-gene-specificity-from-multivariate-single-cell-rna-sequencing-data--2025-11-24-biorxiv`
- Kind: `publication`
- Direction: `incoming`
- URL: <https://sina.bio/publication/determining-gene-specificity-from-multivariate-single-cell-rna-sequencing-data>

This publication contains this grounded claim.

> cell type the dominant source of variation in PBMCs, but also this variation can be largely localized to classical monocytes (Fig. 4b).

Source: 2025-11-24-biorxiv.pdf — <https://sina.bio/source/2025-11-24-biorxiv-pdf>

### Human PBMC variation was dominated by cell type and largely localized to classical monocytes; 105 genes were specific to

- ID: `result:determining-gene-specificity-from-multivariate-single-cell-rna-sequencing-data-4e791ab86b:9d900ff172ccddbbdcee`
- Kind: `result`
- Direction: `incoming`
- URL: <https://sina.bio/result/human-pbmc-variation-was-dominated-by-cell-type-and-largely-localized-t-37007c1c>

This claim supports this result.