--- id: "claim:long-read-sequencing-transcriptome-quantification-with-lr-kallisto-2025-12-01-p-c105976de1:81ae5bd6b5bae9dd336e" kind: "claim" title: "Long-read RNA-seq can detect biologically consequential isoform switching during development." description: "" url: "https://sina.bio/claim/long-read-rna-seq-can-detect-biologically-consequential-isoform-switchi-77ee14de" --- # Long-read RNA-seq can detect biologically consequential isoform switching during development. ## Content Long-read RNA-seq can detect biologically consequential isoform switching during development. ## Metadata ```json { "claim_position": 20, "source_publication_id": "version:long-read-sequencing-transcriptome-quantification-with-lr-kallisto--2025-12-01-plos-computational-biology", "source_work_id": "work:long-read-sequencing-transcriptome-quantification-with-lr-kallisto" } ``` ## Connections (4) ### A new era of long-read sequencing for cancer genomics - ID: `publication:doi:10.1038/s10038-019-0658-5` - Kind: `publication` - Direction: `outgoing` - URL: This publication is cited in support of this claim. > Specifically, long-read > RNA-seq can readily detect gene fusion transcripts and other expressed rearrange- > ments in cancer [4], and isoform switching of biological consequence across develop- > ment [5,6]. Source: 2025-12-01-plos-computational-biology.pdf — ### Integrative genotyping of cancer and immune phenotypes by long-read sequencing - ID: `publication:doi:10.1038/s41467-023-44137-7` - Kind: `publication` - Direction: `outgoing` - URL: This publication is cited in support of this claim. > Specifically, long-read > RNA-seq can readily detect gene fusion transcripts and other expressed rearrange- > ments in cancer [4], and isoform switching of biological consequence across develop- > ment [5,6]. Source: 2025-12-01-plos-computational-biology.pdf — ### Long-read sequencing transcriptome quantification with lr-kallisto - ID: `version:long-read-sequencing-transcriptome-quantification-with-lr-kallisto--2025-12-01-plos-computational-biology` - Kind: `publication` - Direction: `incoming` - URL: This publication contains this grounded claim. > Specifically, long-read RNA-seq can readily detect gene fusion transcripts and other expressed rearrange- ments in cancer [4], and isoform switching of biological consequence across develop- ment [5,6]. Source: 2025-12-01-plos-computational-biology.pdf — ### Single-cell analysis of isoform switching and transposable element expression during preimplantation embryonic development - ID: `publication:doi:10.1371/journal.pbio.3002505` - Kind: `publication` - Direction: `outgoing` - URL: This publication is cited in support of this claim. > Specifically, long-read > RNA-seq can readily detect gene fusion transcripts and other expressed rearrange- > ments in cancer [4], and isoform switching of biological consequence across develop- > ment [5,6]. Source: 2025-12-01-plos-computational-biology.pdf —