---
id: "claim:normalization-for-sampled-count-data-2022-05-06-biorxiv-v1:af5cabb218f00a2a0494"
kind: "claim"
title: "Differential expression, which is the identification of genes exhibiting significantly different expression between grou"
description: "Differential expression, which is the identification of genes exhibiting significantly different expression between groups of cells, is a needed step for marker gene identification, however the latter demands more: good marker genes for a group of cells are not only statistically differential with respect to other cells, but also specifically expressed (i.e. not present in high abundance in other cells)."
url: "https://sina.bio/claim/differential-expression-which-is-the-identification-of-genes-exhibiting-7028efcf"
---

# Differential expression, which is the identification of genes exhibiting significantly different expression between grou

Differential expression, which is the identification of genes exhibiting significantly different expression between groups of cells, is a needed step for marker gene identification, however the latter demands more: good marker genes for a group of cells are not only statistically differential with respect to other cells, but also specifically expressed (i.e. not present in high abundance in other cells).

## Content

Differential expression, which is the identification of genes exhibiting significantly different expression between groups of cells, is a needed step for marker gene identification, however the latter demands more: good marker genes for a group of cells are not only statistically differential with respect to other cells, but also specifically expressed (i.e. not present in high abundance in other cells).

## Metadata

```json
{
  "claim_position": 117,
  "source_publication_id": "version:normalization-for-sampled-count-data--2022-05-06-biorxiv-v1",
  "source_work_id": "work:normalization-for-sampled-count-data"
}
```

## Connections (1)

### Depth normalization for single-cell genomics count data

- ID: `version:normalization-for-sampled-count-data--2022-05-06-biorxiv-v1`
- Kind: `publication`
- Direction: `incoming`
- URL: <https://sina.bio/publication/depth-normalization-for-single-cell-genomics-count-data-25f4bfd9>

This publication contains this grounded claim.

> Differential expression, which is the identification of genes exhibiting significantly different expression between groups of cells, is a needed step for marker gene identification, however the latter demands more: good marker genes for a group of cells are not only statistically differential with respect to other cells, but also specifically expressed (i.e. not present in high abundance in other cells).

Source: 2022-05-06-biorxiv-v1.pdf — <https://sina.bio/source/2022-05-06-biorxiv-v1-pdf>