---
id: "claim:normalization-for-sampled-count-data-2026-06-10-biorxiv-v3:c313a77367702798dba2"
kind: "claim"
title: "Absent depth normalization, transformed matrices can retain depth bias that increases false-positive differential expres"
description: "Absent depth normalization, transformed matrices can retain depth bias that increases false-positive differential expression."
url: "https://sina.bio/claim/absent-depth-normalization-transformed-matrices-can-retain-depth-bias-t-480976b0"
---

# Absent depth normalization, transformed matrices can retain depth bias that increases false-positive differential expres

Absent depth normalization, transformed matrices can retain depth bias that increases false-positive differential expression.

## Content

Absent depth normalization, transformed matrices can retain depth bias that increases false-positive differential expression.

## Metadata

```json
{
  "claim_position": 37,
  "source_publication_id": "version:normalization-for-sampled-count-data--2026-06-10-biorxiv-v3",
  "source_work_id": "work:normalization-for-sampled-count-data"
}
```

## Connections (2)

### Depth normalization for single-cell genomics count data

- ID: `version:normalization-for-sampled-count-data--2026-06-10-biorxiv-v3`
- Kind: `publication`
- Direction: `incoming`
- URL: <https://sina.bio/publication/depth-normalization-for-single-cell-genomics-count-data-13cf6732>

This publication contains this grounded claim.

> transformed matrices can retain sequenc- ing depth bias that inflates false-positive differential expression

Source: 2026-06-10-biorxiv-v3.pdf — <https://sina.bio/source/2026-06-10-biorxiv-v3-pdf>

### Depth-biased transforms perturb graph distances and produced more false-positive differential-expression genes than fina

- ID: `result:normalization-for-sampled-count-data-2026-06-10-biorxiv-v3:733c87f7b440db93c4e2`
- Kind: `result`
- Direction: `incoming`
- URL: <https://sina.bio/result/depth-biased-transforms-perturb-graph-distances-and-produced-more-false-ea201fb8>

This claim supports this result.