--- id: "claim:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-der-cacfaced0c:3728d3dbc407195f5e09" kind: "claim" title: "For example, Spp1 (osteopontin), linked to kidney fibrosis, inflammation, and disease, is regulated by sex hormones70–73" description: "For example, Spp1 (osteopontin), linked to kidney fibrosis, inflammation, and disease, is regulated by sex hormones70–73, and was dif- ferentially upregulated in females in every genotype except CAST (Fig. 2g)." url: "https://sina.bio/claim/for-example-spp1-osteopontin-linked-to-kidney-fibrosis-inflammation-and-ae26111f" --- # For example, Spp1 (osteopontin), linked to kidney fibrosis, inflammation, and disease, is regulated by sex hormones70–73 For example, Spp1 (osteopontin), linked to kidney fibrosis, inflammation, and disease, is regulated by sex hormones70–73, and was dif- ferentially upregulated in females in every genotype except CAST (Fig. 2g). ## Content For example, Spp1 (osteopontin), linked to kidney fibrosis, inflammation, and disease, is regulated by sex hormones70–73, and was dif- ferentially upregulated in females in every genotype except CAST (Fig. 2g). ## Metadata ```json { "claim_position": 93, "source_publication_id": "version:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-derived-mouse-strains-capture-global-and-local-expression-variation--2026-04-cell-genomics", "source_work_id": "work:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-derived-mouse-strains-capture-global-and-local-expression-variation" } ``` ## Connections (3) ### Osteopontin as a Biomarker in Chronic Kidney Disease - ID: `publication:doi:10.3390/biomedicines11051356` - Kind: `publication` - Direction: `outgoing` - URL: This publication is cited in support of this claim. > For example, > Spp1 (osteopontin) is regulated by sex hormones64–67 > and was > differentially upregulated in females in every genotype except > CAST (Figure 2G). Source: 2026-04-cell-genomics.pdf — ### Systematic cell-type resolved transcriptomes of 8 tissues in 8 lab and wild-derived mouse strains capture global and local expression variation - ID: `version:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-derived-mouse-strains-capture-global-and-local-expression-variation--2026-04-cell-genomics` - Kind: `publication` - Direction: `incoming` - URL: This publication contains this grounded claim. > For example, Spp1 (osteopontin) is regulated by sex hormones64–67 and was differentially upregulated in females in every genotype except CAST (Figure 2G). Source: 2026-04-cell-genomics.pdf — ### Most sex-biased renal epithelial genes were genotype-specific, some strains lacked otherwise common sexual dimorphism, a - ID: `result:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-der-cacfaced0c:5b2f302f5c4ff9158464` - Kind: `result` - Direction: `incoming` - URL: This claim supports this result.