---
id: "claim:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-der-cacfaced0c:4fbdf3ab719a61f18146"
kind: "claim"
title: "By systematically character- izing the transcriptional landscape across multiple genotypes and sexes, we demonstrate sig"
description: "By systematically character- izing the transcriptional landscape across multiple genotypes and sexes, we demonstrate significant variability in transcrip- tion between different strains that highlights the importance of considering mouse strain and genetic composition in ex- perimental design and interpretation."
url: "https://sina.bio/claim/by-systematically-character-izing-the-transcriptional-landscape-across-bac19fb8"
---

# By systematically character- izing the transcriptional landscape across multiple genotypes and sexes, we demonstrate sig

By systematically character- izing the transcriptional landscape across multiple genotypes and sexes, we demonstrate significant variability in transcrip- tion between different strains that highlights the importance of considering mouse strain and genetic composition in ex- perimental design and interpretation.

## Content

By systematically character- izing the transcriptional landscape across multiple genotypes and sexes, we demonstrate significant variability in transcrip- tion between different strains that highlights the importance of considering mouse strain and genetic composition in ex- perimental design and interpretation.

## Metadata

```json
{
  "claim_position": 167,
  "source_publication_id": "version:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-derived-mouse-strains-capture-global-and-local-expression-variation--2026-04-cell-genomics",
  "source_work_id": "work:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-derived-mouse-strains-capture-global-and-local-expression-variation"
}
```

## Connections (2)

### Systematic cell-type resolved transcriptomes of 8 tissues in 8 lab and wild-derived mouse strains capture global and local expression variation

- ID: `version:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-derived-mouse-strains-capture-global-and-local-expression-variation--2026-04-cell-genomics`
- Kind: `publication`
- Direction: `incoming`
- URL: <https://sina.bio/publication/systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-02081d03>

This publication contains this grounded claim.

> By sys- tematically characterizing the transcriptional landscape across multiple genotypes and sexes, we demonstrate significant vari- ability in transcription between different strains that highlights the importance of considering mouse strain and genetic composition in experimental design and interpretation

Source: 2026-04-cell-genomics.pdf — <https://sina.bio/source/2026-04-cell-genomics-pdf>

### The impact of genetic background on mouse models of kidney disease

- ID: `publication:doi:10.1016/j.kint.2022.03.020`
- Kind: `publication`
- Direction: `outgoing`
- URL: <https://sina.bio/publication/the-impact-of-genetic-background-on-mouse-models-of-kidney-disease>

This publication is cited in support of this claim.

> 119,120
> By sys-
> tematically characterizing the transcriptional landscape across
> multiple genotypes and sexes, we demonstrate significant vari-
> ability in transcription between different strains that highlights
> the importance of considering mouse strain and genetic
> composition in experimental design and interpretation.

Source: 2026-04-cell-genomics.pdf — <https://sina.bio/source/2026-04-cell-genomics-pdf>