---
id: "claim:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-der-cacfaced0c:e4b2da721df8f013dc12"
kind: "claim"
title: "Heart and brain transcriptomes are relatively similar across strains."
description: ""
url: "https://sina.bio/claim/heart-and-brain-transcriptomes-are-relatively-similar-across-strains"
---

# Heart and brain transcriptomes are relatively similar across strains.

## Content

Heart and brain transcriptomes are relatively similar across strains.

## Metadata

```json
{
  "claim_position": 6,
  "source_publication_id": "version:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-derived-mouse-strains-capture-global-and-local-expression-variation--2026-04-cell-genomics",
  "source_work_id": "work:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-derived-mouse-strains-capture-global-and-local-expression-variation"
}
```

## Connections (1)

### Systematic cell-type resolved transcriptomes of 8 tissues in 8 lab and wild-derived mouse strains capture global and local expression variation

- ID: `version:systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-wild-derived-mouse-strains-capture-global-and-local-expression-variation--2026-04-cell-genomics`
- Kind: `publication`
- Direction: `incoming`
- URL: <https://sina.bio/publication/systematic-cell-type-resolved-transcriptomes-of-8-tissues-in-8-lab-and-02081d03>

This publication contains this grounded claim.

> Mapping the impact of genomic variation on gene expression provides insight into the molecular basis of complex phenotypic traits and disease predisposition. Mouse models offer a controlled framework to cap- ture genomic diversity across tissues. As part of theIGVF consortium, we profiled thetranscriptomes ofeight tissuesfromeachfounderstrainoftheCollaborativeCrossusingsingle-nucleusRNAsequencing. Theresult- ing ''8-cube''dataset contains 5.2 million nuclei across 106 cell types and cell states. Transcriptome variation correlated with genetic divergence,highest inthewild-derived strains. Heart andbrain wererelatively similar, whereasgonads,adrenalgland,skeletalmuscle,kidney,andlivershowedgreaterdivergence.Variationoften concentrated in specific cell types and states, especially those linked to immune and metabolic traits. The founder 8-cube dataset provides rich transcriptome signatures to help explain strain-specific traits and dis- ease states and serves as afoundation fordeeper analysisofthese tissues across diverse mouse genotypes.

Source: 2026-04-cell-genomics.pdf — <https://sina.bio/source/2026-04-cell-genomics-pdf>