---
id: "claim:the-impact-of-package-selection-and-versioning-on-single-cell-rna-seq-analysis-3717bd8a9e:1d6b936d63f899926fb0"
kind: "claim"
title: "Default HVG sets had Jaccard overlap 0.22."
description: ""
url: "https://sina.bio/claim/default-hvg-sets-had-jaccard-overlap-0-22-6f9b2f60"
---

# Default HVG sets had Jaccard overlap 0.22.

## Content

Default HVG sets had Jaccard overlap 0.22.

## Metadata

```json
{
  "claim_position": 17,
  "source_publication_id": "version:the-impact-of-package-selection-and-versioning-on-single-cell-rna-seq-analysis--2026-04-cell-systems",
  "source_work_id": "work:the-impact-of-package-selection-and-versioning-on-single-cell-rna-seq-analysis"
}
```

## Connections (2)

### The impact of package selection and versioning on single-cell RNA-seq analysis

- ID: `version:the-impact-of-package-selection-and-versioning-on-single-cell-rna-seq-analysis--2026-04-cell-systems`
- Kind: `publication`
- Direction: `incoming`
- URL: <https://sina.bio/publication/the-impact-of-package-selection-and-versioning-on-single-cell-rna-seq-a-dae7bb70>

This publication contains this grounded claim.

> the programs deviated from their default
> algorithm for HVG selection, with a Jaccard index (intersection
> over union between two sets) of 0.22 (p <0:001)

Source: 2026-04-cell-systems.pdf — <https://sina.bio/source/2026-04-cell-systems-pdf>

### Default Seurat and Scanpy filtering and matched log normalization produce identical cells, genes, and normalized values,

- ID: `result:the-impact-of-package-selection-and-versioning-on-single-cell-rna-seq-analysis-3717bd8a9e:89126c39c9e195229063`
- Kind: `result`
- Direction: `incoming`
- URL: <https://sina.bio/result/default-seurat-and-scanpy-filtering-and-matched-log-normalization-produ-364f2e47>

This claim supports this result.