Characterization of spatial homogeneous regions in tissues with concordex

Spatially resolved transcriptomics enables study of gene-expression variation across tissues, but cell-type spatial distributions confound identification of spatially variable genes. Analyses therefore need to distinguish cell-type-distribution effects from cell-type-independent spatial effects. concordex identifies cell-type-homogeneous domains efficiently across platforms and tissue types, facilitating decomposition of expression into cell-type and spatial variation and revealing subtle gene-variation patterns.